Cancer Without Disease

I heard this somewhere today. Cancer Without Disease. Which led me to look at this. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.


Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. Continue reading Cancer Without Disease

Mel’s Diner

Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products.

– Melatonin has been described to possess cell protecting activity in normal cells but was shown to induce apoptotic cell death in cancer cells. It potentiates apoptosis induced by the flavonoid flavone significantly. A combination of flavone and melatonin increased caspase-3-like activity 30-fold and 80% of cells exhibited fragmentation of DNA when compared to untreated controls. Melatonin caused an increase in cytosolic lactate levels that most likely allows the flavone-induced activation of the mitochondrial pyruvate/lactate importer to deliver more substrates to mitochondrial respiration.

Melatonin Enhances the Anti-Tumor Effect of Fisetin

– Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells.

 

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Melatonin Enhances the Anti-Tumor Effect of Fisetin

An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer – Flavonoids, Flavonols, Quercetin, Kaempferol, Myricetin, Fisetin, Rutin, Flavanones, Hesperidin, Naringenin, Silibinin, Eriodictyol, Flavones, Acacetin, Apigenin, Chrysin, Tangeretin, Luteolin, Baicalein, Nobiletin, Flavan-3-ols (flavanols), Catechins, Proanthocyanidin, Flavanonols, Pelargonidin, Peonidin, Cyanidin, Delphinidin, Malvidin.

PDFAn Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer

Medical and Dietary Uses of N-Acetylcysteine

Microbes in the Era of Circadian Medicine

Bacterial circadian rhythm | Circadian advantage

Your Body, Your System – Dr. Shiva

Escin induces caspase-dependent apoptosis and autophagy

How do anti-mitotic drugs kill cancer cells?

Anti-tubulin antibodies in autoimmune thyroid disorders.

Mitotic inhibitor

Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells.

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Who Had Their Finger on the Magic of Life – Antoine Bechamp or Louis Pasteur?

PDF | CELLULAR SENESCENCE- AGING, CANCER, AND INJURY

Inducers of Senescence, Toxic Compounds, and Senolytics – We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.

Cancer, aging and cellular senescence – Normal cells do not Continue reading linkRoll_2020.04.13

Fighting Fisetin

What an incredibly tool in the hands of a skilled craftsman. The following is my unwieldy rack of tabs. As of April 07, 2020.


Sensing seriousness about senolytics

www.fightaging.comFisetin – Animal data shows fisetin to be a surprisingly effective senolytic

Forever Healthy Knowledge Base

Fisetin Senolytic Therapy

Anticancer Efficacy of Polyphenols and Their Combinations

Blocking negative effects of senescence in human skin fibroblasts with a plant extracts